Tibolone dosage, side effects

Tibolone dosage, side effects:

Tibolone is a synthetic steroid with estrogenic, progestogenic, and androgenic properties. It is primarily used for hormone replacement therapy (HRT) in postmenopausal women to alleviate symptoms like hot flashes, vaginal dryness, and osteoporosis.

• Estrogenic Effects: Tibolone and its metabolites activate estrogen receptors, providing relief from menopausal symptoms and preventing bone loss.
• Progestogenic Effects: It also acts on progesterone receptors, offering protective effects on the endometrium.
• Androgenic Effects: Tibolone has mild androgenic activity, which can improve libido and overall well-being.

• Menopausal Symptom Relief: Reduces hot flashes, night sweats, and vaginal dryness.
• Osteoporosis Prevention: Helps maintain bone density in postmenopausal women.
• Libido Enhancement: May improve sexual desire due to its androgenic effects.

• Typical Dosage: 2.5 mg once daily.
• Administration: Oral tablets, taken consistently at the same time each day.

• Common: Headache, breast tenderness, vaginal bleeding, weight changes.
• Serious: Increased risk of stroke, venous thromboembolism, and certain cancers (e.g., breast cancer).

• Pregnancy and Breastfeeding: Not recommended.
• History of Hormone-Sensitive Cancers: Such as breast or endometrial cancer.
• Thromboembolic Disorders: History of blood clots.
• Liver Disease: Severe hepatic impairment.

Tibolone is marketed under various brand names globally, including:

• Livial: One of the most widely recognized brand names.
• Boltin
• Sibelia
• Tibofem
• Tibofemme

• Regions: Available in Europe, Asia, and some other regions, but not approved in the United States.
• Prescription: Requires a prescription and should be used under medical supervision.

• Regular Check-Ups: To monitor for side effects and efficacy.
• Bone Density Tests: For women using it for osteoporosis prevention.
• Mammograms: Regular breast cancer screening is advised.

Tibolone is a versatile hormone replacement therapy option for postmenopausal women, offering benefits for menopausal symptoms, bone health, and sexual well-being. However, it comes with potential risks and should be used under strict medical supervision. Always consult a healthcare provider for personalized advice.